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Data presented show that the new testosterone replacement therapy, testosterone gel, which is available commercially as AndroGel® (testosterone gel) 1% CIII, improves sexual function, mood, muscle strength, bone mineral density and body composition in testosterone deficient men. Data also showed that this testosterone gel in the doses selected for the study gave consistent levels of testosterone in the blood that were higher than the usually recommended dose of a testosterone patch. This data, representing a study conducted by 16 research centers in the United States, was presented at the current ENDO 2000, the annual meeting of the Endocrine Society.

The 227-man study, comparing a new testosterone gel (AndroGel 5g to 10 g/day) to the testosterone patch Androderm® (5mg/day), was the largest ever performed on men with low testosterone. The three arms of the study produced blood testosterone levels in the low normal, mid-normal and high normal range with the testosterone patch, low dose and high dose testosterone gels respectively. The study found that skin irritation was reported in only 5.5 percent of men using AndroGel, compared with 66 percent of men using the patch. Data also indicated that the testosterone gel in the 10g/day group significantly increased bone mineral density in the hip and spine as compared with the lower dose of testosterone gel and the patch, which showed no increase in bone mineral density.

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Division of Endocrinology (C.W., N.B., L.H., R.S.S.), Departments of Medicine/Pediatrics, Harbor-University of California, Los Angeles Medical Center and Research and Education Institute, Torrance, California 90509; Veterans Affairs Medical Center (G.C.), Baylor College of Medicine, Houston, Texas 77030; Johns Hopkins University (A.D.), Baltimore, Maryland 21287; Veterans Affairs Medical Center (A.I.), Salem, Virginia 24153; Geriatric Research (A.M.M.), Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington 98108; University of Pennsylvania Medical Center (P.J.S.), Philadelphia,

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